Possible applications & planning

The potential applications for our invention are broad, because there are many health conditions where weight gain can lead to health benefits.

To prove that our invention works in patients we are in preparation for Phase 2a studies in the following indications:


Post-operative ileus:

Post-operative ileus (POI) occurs in approximately 50% of patients who undergo major abdominal surgery (Kuruba et al., 2018). POI is characterized by the inability to tolerate a solid diet, delayed passage of flatus and formed stool, pain and abdominal distension, nausea, vomiting, and accumulation of gas or fluids in the bowel. The causes of POI are multi factorial and include surgical manipulation, inflammatory response, inhibitory neural reflexes, and the secretion of endogenous opioids within the gastrointestinal tract.

Every year approximately 10 million patients undergo major abdominal surgery in the US and EU.

We indicate a peak sales in the order of EUR 200–400M per year for POI.

Cachexia & Sarcopenia:

Cachexia is the loss of weight and muscle strength as a consequence of underlying disease (like cancer).

Sarcopenia is the loss of weight and muscle strength purely as a consequence of ageing. It is caused by changes in food intake and activity.

These are huge markets and we indicate a peak sales of > EUR 1 billion per year for Cachexia & Sarcopenia, if we can prove sufficient health benefits.